Scientific Vita
Publi­cations
Con­tact

Prof. Dr. Dr.

Stephan Urban

Academic Education and University Degrees

2000
Habilitation at the faculty for Biosciences, venia legendi Molecular Biology at the Ruprecht-Karls-University Heidelberg, Germany
1995 - 2000
Post doctoral fellow at the ZMBH Heidelberg (Prof Dr. Heinz Schaller).
1991 - 1995
Ph.D. thesis, Dept. of Virology supervised by Prof. Dr. P. H. Hofschneider, Max-Planck-Institute for Biochemistry, Martinsried, Germany.
1991
Diploma in Biochemistry at the University of Tübingen, Germany.
1982 - 1987
Study of Chemistry, Biochemistry and Philosophy in Tübingen and Munich, Germany.

Employment

2014 - present
Full professor (W3) “Translational Virology” at the Medical Faculty of the Heidelberg University, Germany.
2008 - 2014
Professorship (apl.) at the Faculty for Biosciences at Heidelberg University, Germany
2001 - present
Research group leader at the Department of Infectious Diseases, Molecular Virology of the University Hospital Heidelberg, Germany.
2000 - 2001
Stipendium of the Schaller foundation at the ZMBH, Heidelberg, Germany.
1. Hollnberger J, Liu Y, Xu S, Chang S, Martin R, Manhas S, Aeschbacher T, Han B, Yazdi T, May L, Han D, Shornikov A, Flaherty J, Manuilov D, Suri V, Asselah T, Lampertico P, Wedemeyer H, Aleman S, Richards C, Mateo R, Maiorova E, Cihlar T, Mo H, Urban S. (2023) No virologic resistance to bulevirtide monotherapy detected in patients through 24 weeks treatment in phase II and III clinical trials for chronic hepatitis delta. J. Hepatol. doi: 10.1016/j.jhep.2023.04.027
2. Wedemeyer H, Schöneweis K, Bogomolov P, Blank A, Voronkova N, Stepanova T, Sagalova O, Chulanov V, Osipenko M, Morozov V, Geyvandova N, Sleptsova S, Bakulin I, Khaertynova I, Rusanova M, Pathil A, Merle U, Bremer B, Allweiss L, Lempp F, Port K, Haag M, Schwab M, Schulze zur Wiesch J, Cornberg M, Haefeli W, Dandri M, Alexandrov A, Urban S. (2023) Safety and efficacy of bulevirtide in combination with tenofovir disoproxil fumarate in patients with hepatitis B virus and hepatitis D virus coinfection (MYR202): a multicentre, randomised, parallel-group, open-label, phase 2 trial. Lancet Infect Dis 23(1):117-129. doi:10.1016/S1473-3099(22)00318-8
3. Bogomolov P, Alexandrov A, Voronkova N, Macievich M, Kokina K, Petrachenkova M, Lehr T, Lempp FA, Wedemeyer H, Haag M, Schwab M, Haefeli WE, Blank A, Urban S. (2016) Treatment of chronic hepatitis D with the entry inhibitor myrcludex B: First results of a phase Ib/IIa study. J. Hepatol 65(3):490-8. doi: 10.1016/j.jhep.2016.04.016
3. Hoh A, Heeg M, Ni Y, Schuch A, Binder B, Hennecke N, Blum HE, Nassal M, Protzer U, Hofmann M, Urban S, Thimme R. HBV-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro. J Virol. 2015. May 13. pii: JVI.00605-15. doi: 10.1128/JVI.00605-15
4. Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Fälth M, Stindt J, Königer C, Nassal M, Kubitz R and Urban S. (2014) Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology 14;146:1070-1083. doi: 10.1053/j.gastro.2013.12.024
5. Urban S, Bartenschlager R, Kubitz R, Zoulim F. (2014) Strategies to inhibit entry of HBV and HDV into hepatocytes. Gastroenterology 14;7:48-64. doi: 10.1053/j.gastro.2014.04.030
6. Petersen J, Dandri M, Mier W, Lutgehetmann M, Volz T, von WF, Haberkorn U, Fischer L, Pollok JM, Erbes B, Seitz S, Urban S. (2008) Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nat Biotechnol. 26:335-341. doi: 10.1038/nbt1389
7. Seitz S*, Urban S*, Antoni C and Böttcher B. (2007) Cryo-electron microscopy of hepatitis B virions reveals variability in envelope capsid interactions. EMBO J. 26:4160-4167. doi: 10.1038/sj.emboj.7601841 * equal contribution
8. Gripon P, Cannie I, Urban S. 2005 Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein. J. Virol. 79(3):1613-22. doi: 10.1128/JVI.79.3.1613-1622.2005
9. Gripon P, Rumin S, Urban S, Le Seyec J, Glaise D, Cannie I, Guyomard C, Lucas J, Trepo C, Guguen-Guillouzo C. (2002) Infection of a human hepatoma cell line by hepatitis B virus. Proc Natl Acad Sci U S A., 99(24):15655-15660. doi: 10.1073/pnas.232137699
Address
Department of Infectious Diseases
Molecular Virology Medical Faculty
Heidelberg University
Im Neuenheimer Feld 345
69120 Heidelberg
eMail
stephan.urban@med.uni-heidelberg.de