Scientific Vita
Publi­cations
Con­tact

APL Prof. Dr.

Volker Lohmann

Academic Education and University Degrees

2012
Habilitation in Experimental Virology, Heidelberg University, Germany, mentor: Prof. Dr. Ralf Bartenschlager
1993 - 1998
Ph.D. thesis, Molecular Biology, Center for Molecular Biology, Heidelberg, Germany (Grade: summa cum laude) supervised by Prof. Dr. Ralf Bartenschlager
1992 - 1993
Diploma work, Biology, University Hospital Mainz, Germany, Experimental Virology, supervised by Prof. Dr. Dietrich Falke
1987 - 1993
Study of Biology at University of Mainz, Germany

Employment

Since 2020
Head of section "Virus-Host-Interactions"
Since 2019
Apl. Prof. at Heidelberg University
Since 2018
Deputy head of Department of Infectious Diseases, Molecular Virology
Since 02/2002
Group leader at the Department Infectious Diseases, Molecular Virology, Heidelberg University, Germany
1998 - 2002
Postdoc at the Institute for Virology, University of Mainz, Germany
1. Colasanti O, Burm R, Huang HE, Riedl T, Traut J, Gillich N, Li TF, Corneillie L, Faure-Dupuy S, Grünvogel O, Heide D, Lee JY, Tran CS, Merle U, Chironna M, Vondran FFW, Esser-Nobis K, Binder M, Bartenschlager R, Heikenwälder M, Meuleman P, Lohmann V. (2023) Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation. J Hepatol. S0168-8278(23)00309-4. doi: 10.1016/j.jhep.2023.04.023.
2. Heuss C, Rothhaar P, Burm R, Lee JY, Ralfs P, Haselmann U, Ströh LJ, Colasanti O, Tran CS, Schäfer N, Schnitzler P, Merle U, Bartenschlager R, Patel AH, Graw F, Krey T, Laketa V, Meuleman P, Lohmann V. (2022) A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo. PLoS Pathog. 18(6):e1010472. doi: 10.1371/journal.ppat.1010472.
3. Grünvogel O, Colasanti O, Lee J-Y, Klöss V, Belouzard S, Reustle A, Esser-Nobis K, Hesebeck-Brinckmann J, Mutz P, Hoffmann K, Mehrabi A, Koschny R, Vondran FWR, Gotthardt D, Schnitzler P, Neumann-Haefelin C, Thimme R, Binder M, Bartenschlager R, Dubuisson J, Dalpke AH, Lohmann V. (2018) Secretion of Hepatitis C virus replication intermediates reduces activation of toll like receptor 3 in hepatocytes. Gastroenterology. 154(8):2237-2251.e16. doi: 10.1053/j.gastro.2018.03.020.
4. Doerflinger SY, Cortese M, Romero-Brey I, Menne Z, Tubiana T, Schenk C, White PA, Bartenschlager R, Bressanelli S, Hansman GS, Lohmann V. (2017) Membrane alterations induced by nonstructural proteins of human norovirus. PLoS Pathog. 13(10):e1006705. doi: 10.1371/journal.ppat.1006705.
5. Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, Francesco R, Rice CM, Bartenschlager R, Lohmann V. (2016) Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture. Nat Microbiol. 2:16247. doi: 10.1038/nmicrobiol.2016.247.
6. Esser-Nobis K, Harak C, Schult P, Kusov Y, Lohmann V. (2015) Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replication. Hepatology. 62(2):397-408. doi: 10.1002/hep.27847.
7. Esser-Nobis K, Romero-Brey I, Ganten TM, Gouttenoire J, Harak C, Klein R, Schemmer P, Binder M, Schnitzler P, Moradpour D, Bartenschlager R, Polyak SJ, Stremmel W, Penin F, Eisenbach C, Lohmann V. (2013) Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B. Hepatology 57:953-963. doi:10.1002/hep.2626.
8. Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V. (2013) The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A. PLoS.Pathog. 9:e1003359. doi:10.1371/journal.ppat.1003359.
9. Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Buhler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V*, Bartenschlager R.* (2011) Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe 9:32-45. doi: 10.1016/j.chom.2010.12.002. *co-corresponding authors.
10. Lohmann V, Körner F, Koch JO, Herian U, Theilmann L, Bartenschlager R. (1999) Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285:110-113. doi: 10.1126/science.285.5424.110.
Address
Department of Infectious Diseases,
Molecular Virology Medical Faculty,
Heidelberg University
Im Neuenheimer Feld 344
69120 Heidelberg
eMail
volker.lohmannn@med.uni-heidelberg.de